Assay Detail
Binding
CHEMBL744930
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Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.72 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305119 | — | — | 1 | 8.82 |
| CHEMBL65468 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305119 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL65468 | — | Ki | = | 2.4 | nM | 8.62 |