Assay Detail
Binding
CHEMBL744931
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In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Articulating a pharmacophore driven synthetic strategy: Discovery of a potent substance P antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.72 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | — | 1 | 8.82 |
| CHEMBL55591 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL55591 | — | Ki | = | 2.4 | nM | 8.62 |