Assay Detail

CHEMBL745032

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Binding

Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL4027) ↗

Open DB target context

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Primary target Substance-P receptor

CHEMBL4027

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Tissue	Duodenum
Subcellular	Membrane
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Substance-P receptor (CHEMBL4027) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

A facile synthesis of the novel Neurokinin A antagonist SR 48968

Hale JJ, Finke PE, MacCoss M
Bioorg Med Chem Lett (1993) 3 : 319 -322
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.29	9.29

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL308148	SAREDUTANT	3.0	1	9.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL308148	SAREDUTANT	Ki	=	0.51	nM	9.29