Assay Detail
Binding
CHEMBL745034
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Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quinuclidine based NK-1 antagonists 2: determination of the absolute stereochemical requirements
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.71 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49638 | — | — | 1 | 9.15 |
| CHEMBL22194 | L-709210 | — | 1 | 8.89 |
| CHEMBL296228 | — | — | 1 | 6.57 |
| CHEMBL297068 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49638 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL22194 | L-709210 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL296228 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL297068 | — | IC50 | = | 570.0 | nM | 6.24 |