Assay Detail
Binding
CHEMBL745038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297327 | — | — | 1 | 5.00 |
| CHEMBL444832 | — | — | 1 | 5.00 |
| CHEMBL295301 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297327 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL444832 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL295301 | — | IC50 | = | 10000.0 | nM | 5.00 |