Assay Detail
Binding
CHEMBL745040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.36 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.30 |
| CHEMBL283356 | L-706125 | — | 1 | 9.00 |
| CHEMBL280849 | — | — | 1 | 7.68 |
| CHEMBL29487 | — | — | 1 | 7.32 |
| CHEMBL431690 | — | — | 1 | 6.82 |
| CHEMBL29293 | — | — | 1 | 6.74 |
| CHEMBL429610 | — | — | 1 | 6.71 |
| CHEMBL30139 | — | — | 1 | 6.54 |
| CHEMBL282996 | — | — | 1 | 6.16 |
| CHEMBL29993 | — | — | 1 | - |
| CHEMBL287674 | — | — | 1 | - |
| CHEMBL29785 | — | — | 1 | - |
| CHEMBL281502 | — | — | 1 | - |
| CHEMBL29760 | — | — | 1 | - |
| CHEMBL281703 | — | — | 1 | - |
| CHEMBL29786 | — | — | 1 | - |
| CHEMBL30029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL283356 | L-706125 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL280849 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL29487 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL431690 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL29293 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL429610 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL30139 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL282996 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL29993 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL287674 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29785 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL281502 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29760 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL281703 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29786 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL30029 | — | IC50 | = | 110000.0 | nM | - |