Assay Detail
Functional
CHEMBL745043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functional potency
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha2/beta4 (CHEMBL3038459) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.73 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111659 | ALTINICLINE | 2.0 | 2 | 5.30 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.00 |
| CHEMBL111580 | — | — | 2 | 4.82 |
| CHEMBL1788226 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111659 | ALTINICLINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3 | NICOTINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL111580 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1788226 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL111580 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL111659 | ALTINICLINE | EC50 | = | 49000.0 | nM | 4.31 |