Assay Detail
Functional
CHEMBL745136
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Inhibition of proliferation of PMA and Ionomycin stimulated murine T cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Murine T-cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.52 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.16 |
| CHEMBL276729 | — | — | 1 | 9.10 |
| CHEMBL274802 | — | — | 1 | 9.05 |
| CHEMBL417787 | — | — | 1 | 9.05 |
| CHEMBL8423 | — | — | 1 | 8.96 |
| CHEMBL8875 | — | — | 1 | 8.92 |
| CHEMBL8513 | — | — | 1 | 8.85 |
| CHEMBL276650 | — | — | 1 | 8.80 |
| CHEMBL414821 | — | — | 1 | 8.79 |
| CHEMBL8404 | — | — | 1 | 8.77 |
| CHEMBL267529 | — | — | 1 | 8.59 |
| CHEMBL8189 | — | — | 1 | 8.59 |
| CHEMBL8873 | — | — | 1 | 8.57 |
| CHEMBL414211 | — | — | 1 | 8.49 |
| CHEMBL430326 | — | — | 1 | 8.47 |
| CHEMBL269165 | — | — | 1 | 8.47 |
| CHEMBL273971 | — | — | 1 | 8.28 |
| CHEMBL276664 | — | — | 1 | 8.27 |
| CHEMBL262698 | — | — | 1 | 8.27 |
| CHEMBL263971 | — | — | 1 | 8.22 |
| CHEMBL425969 | — | — | 1 | 7.45 |
| CHEMBL216313 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL276729 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL274802 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL417787 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL8423 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL8875 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL8513 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL276650 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL414821 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL8404 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL267529 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL8189 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL8873 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL414211 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL430326 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL269165 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL273971 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL276664 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL262698 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL263971 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL425969 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL216313 | — | IC50 | = | 607.0 | nM | 6.22 |