Assay Detail
Binding
CHEMBL745320
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Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.21 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288371 | — | — | 1 | 8.70 |
| CHEMBL289666 | — | — | 1 | 8.30 |
| CHEMBL131171 | — | — | 1 | 8.10 |
| CHEMBL288942 | — | — | 1 | 7.58 |
| CHEMBL291146 | — | — | 1 | 7.39 |
| CHEMBL41375 | — | — | 1 | 7.11 |
| CHEMBL297244 | — | — | 1 | 6.33 |
| CHEMBL38824 | DAPITANT | 2.0 | 1 | 5.85 |
| CHEMBL295845 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288371 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL289666 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL131171 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL288942 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL291146 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL41375 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL297244 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL38824 | DAPITANT | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL295845 | — | IC50 | = | 3000.0 | nM | 5.52 |