Assay Detail
Functional
CHEMBL745419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in non-NTR-expressing mouse mammary carcinoma cell line (EMT6).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Mammary carcinoma cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.38 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288377 | — | — | 1 | 9.96 |
| CHEMBL37705 | — | — | 1 | 9.43 |
| CHEMBL314487 | — | — | 1 | 8.72 |
| CHEMBL84381 | — | — | 1 | 7.62 |
| CHEMBL314247 | — | — | 1 | 7.48 |
| CHEMBL314246 | — | — | 1 | 7.36 |
| CHEMBL311087 | — | — | 1 | 7.33 |
| CHEMBL313563 | — | — | 1 | 7.32 |
| CHEMBL83545 | — | — | 1 | 7.20 |
| CHEMBL79354 | — | — | 1 | 7.13 |
| CHEMBL311195 | — | — | 1 | 7.10 |
| CHEMBL78019 | — | — | 1 | 6.97 |
| CHEMBL316382 | — | — | 1 | 6.76 |
| CHEMBL84463 | — | — | 1 | 6.71 |
| CHEMBL311598 | — | — | 1 | 6.68 |
| CHEMBL23612 | — | — | 1 | 4.27 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288377 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL37705 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL314487 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL84381 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL314247 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL314246 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL311087 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL313563 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL83545 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL79354 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL311195 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL78019 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL316382 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL84463 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL311598 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL23612 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 710000.0 | nM | - |