Assay Detail
Binding
CHEMBL745529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL317) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.61 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131865 | — | — | 1 | 8.84 |
| CHEMBL1202004 | — | — | 1 | 8.55 |
| CHEMBL265256 | TRIPITRAMINE | — | 1 | 7.94 |
| CHEMBL112244 | — | — | 1 | 7.80 |
| CHEMBL335115 | — | — | 1 | 7.70 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.49 |
| CHEMBL1202001 | — | — | 1 | 7.44 |
| CHEMBL1202000 | — | — | 1 | 7.40 |
| CHEMBL1202003 | — | — | 1 | 7.38 |
| CHEMBL134692 | — | — | 1 | 7.20 |
| CHEMBL1202002 | — | — | 1 | 6.80 |
| CHEMBL407678 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131865 | — | Ki | = | 1.445 | nM | 8.84 |
| CHEMBL1202004 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL265256 | TRIPITRAMINE | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL112244 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL335115 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL1202001 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL1202000 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1202003 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL134692 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1202002 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL407678 | — | Ki | = | 158.49 | nM | 6.80 |