Assay Detail
Binding
CHEMBL745569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Mapping property distributions of molecular surfaces: algorithm and evaluation of a novel 3D quantitative structure-activity relationship technique.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 5.90 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609382 | — | — | 1 | 7.35 |
| CHEMBL609120 | — | — | 1 | 7.22 |
| CHEMBL30939 | — | — | 1 | 7.20 |
| CHEMBL31376 | — | — | 1 | 7.18 |
| CHEMBL32530 | — | — | 1 | 7.15 |
| CHEMBL284393 | — | — | 1 | 7.07 |
| CHEMBL27743 | — | — | 1 | 6.94 |
| CHEMBL31380 | — | — | 1 | 6.83 |
| CHEMBL285811 | — | — | 1 | 6.49 |
| CHEMBL28407 | — | — | 1 | 6.41 |
| CHEMBL284962 | — | — | 1 | 6.40 |
| CHEMBL32676 | — | — | 1 | 6.34 |
| CHEMBL31452 | — | — | 1 | 6.28 |
| CHEMBL31518 | — | — | 1 | 6.24 |
| CHEMBL284055 | — | — | 1 | 6.13 |
| CHEMBL609124 | — | — | 1 | 6.13 |
| CHEMBL31097 | — | — | 1 | 6.10 |
| CHEMBL262124 | — | — | 1 | 6.10 |
| CHEMBL281080 | — | — | 1 | 6.00 |
| CHEMBL609125 | — | — | 1 | 6.00 |
| CHEMBL285598 | — | — | 1 | 5.90 |
| CHEMBL286892 | — | — | 1 | 5.86 |
| CHEMBL31599 | — | — | 1 | 5.84 |
| CHEMBL30376 | — | — | 1 | 5.80 |
| CHEMBL31162 | — | — | 1 | 5.70 |
| CHEMBL30361 | — | — | 1 | 5.66 |
| CHEMBL280535 | — | — | 1 | 5.64 |
| CHEMBL285136 | — | — | 1 | 5.63 |
| CHEMBL31895 | — | — | 1 | 5.57 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609382 | — | EC50 | = | 44.98 | nM | 7.35 |
| CHEMBL609120 | — | EC50 | = | 59.98 | nM | 7.22 |
| CHEMBL30939 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL31376 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL32530 | — | EC50 | = | 70.79 | nM | 7.15 |
| CHEMBL284393 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL27743 | — | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL31380 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL285811 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL28407 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL284962 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL32676 | — | EC50 | = | 457.09 | nM | 6.34 |
| CHEMBL31452 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL31518 | — | EC50 | = | 570.16 | nM | 6.24 |
| CHEMBL609124 | — | EC50 | = | 739.61 | nM | 6.13 |
| CHEMBL284055 | — | EC50 | = | 741.31 | nM | 6.13 |
| CHEMBL31097 | — | EC50 | = | 799.83 | nM | 6.10 |
| CHEMBL262124 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL281080 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL609125 | — | EC50 | = | 990.83 | nM | 6.00 |
| CHEMBL285598 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL286892 | — | EC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL31599 | — | EC50 | = | 1438.8 | nM | 5.84 |
| CHEMBL30376 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL31162 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL30361 | — | EC50 | = | 2197.86 | nM | 5.66 |
| CHEMBL280535 | — | EC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL285136 | — | EC50 | = | 2344.23 | nM | 5.63 |
| CHEMBL31895 | — | EC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL27673 | METHOCTRAMINE | EC50 | = | 2999.16 | nM | 5.52 |
| CHEMBL282782 | — | EC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL286686 | — | EC50 | = | 4497.8 | nM | 5.35 |
| CHEMBL31103 | — | EC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL30264 | — | EC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL31915 | — | EC50 | = | 8810.49 | nM | 5.05 |
| CHEMBL177732 | — | EC50 | = | 9772.37 | nM | 5.01 |
| CHEMBL31475 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL31336 | — | EC50 | = | 12105.98 | nM | 4.92 |
| CHEMBL31533 | — | EC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 30974.19 | nM | 4.51 |
| CHEMBL31221 | — | EC50 | = | 31988.95 | nM | 4.50 |
| CHEMBL284672 | — | EC50 | = | 53951.06 | nM | 4.27 |
| CHEMBL30669 | — | EC50 | = | 110917.48 | nM | - |
| CHEMBL31385 | — | EC50 | = | 151008.02 | nM | - |