Assay Detail
Binding
CHEMBL746732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116733 | — | — | 1 | 6.68 |
| CHEMBL419940 | — | — | 1 | 6.26 |
| CHEMBL50267 | — | — | 1 | 6.07 |
| CHEMBL324519 | — | — | 1 | 5.14 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116733 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL419940 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL50267 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL324519 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL299155 | TRANSTORINE | IC50 | = | 40200.0 | nM | 4.40 |