Assay Detail
Binding
CHEMBL746846
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Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.84 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169638 | — | — | 1 | 6.46 |
| CHEMBL168840 | — | — | 1 | 6.43 |
| CHEMBL169633 | — | — | 1 | 6.35 |
| CHEMBL352486 | — | — | 1 | 6.33 |
| CHEMBL169342 | — | — | 1 | 6.29 |
| CHEMBL354103 | — | — | 1 | 6.29 |
| CHEMBL169475 | — | — | 1 | 6.28 |
| CHEMBL352323 | — | — | 1 | 6.28 |
| CHEMBL169001 | — | — | 1 | 6.24 |
| CHEMBL168613 | — | — | 1 | 6.20 |
| CHEMBL168760 | — | — | 1 | 5.86 |
| CHEMBL171664 | — | — | 1 | 5.85 |
| CHEMBL266295 | — | — | 1 | 5.84 |
| CHEMBL171388 | — | — | 1 | 5.72 |
| CHEMBL171776 | — | — | 1 | 5.63 |
| CHEMBL165814 | — | — | 1 | 5.57 |
| CHEMBL352356 | — | — | 1 | 5.46 |
| CHEMBL353262 | — | — | 1 | 5.42 |
| CHEMBL354750 | — | — | 1 | 5.33 |
| CHEMBL354673 | — | — | 1 | 5.31 |
| CHEMBL171215 | — | — | 1 | 5.05 |
| CHEMBL169133 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169638 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL168840 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL169633 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL352486 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL169342 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL354103 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL169475 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL352323 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL169001 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL168613 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL168760 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL171664 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL266295 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL171388 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL171776 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL165814 | — | EC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL352356 | — | EC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL353262 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL354750 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL354673 | — | EC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL171215 | — | EC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL169133 | — | EC50 | = | 50800.0 | nM | 4.29 |