Assay Detail
Binding
CHEMBL746909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit MK-801 binding to NMDA receptor in the presence of 100 uM of spermidine was determined
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.72 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432447 | — | — | 1 | 5.65 |
| CHEMBL117961 | — | — | 1 | 5.23 |
| CHEMBL115850 | — | — | 1 | 5.15 |
| CHEMBL333241 | — | — | 1 | 5.03 |
| CHEMBL117030 | — | — | 1 | 5.00 |
| CHEMBL325856 | — | — | 1 | 4.98 |
| CHEMBL118521 | — | — | 1 | 4.92 |
| CHEMBL118520 | — | — | 1 | 4.80 |
| CHEMBL117622 | — | — | 1 | 4.69 |
| CHEMBL117808 | — | — | 1 | 4.53 |
| CHEMBL117463 | — | — | 1 | 4.31 |
| CHEMBL116027 | — | — | 1 | 4.26 |
| CHEMBL115747 | — | — | 1 | 4.12 |
| CHEMBL102740 | ARCAINE | — | 1 | 4.10 |
| CHEMBL116333 | — | — | 1 | 4.02 |
| CHEMBL117468 | — | — | 1 | - |
| CHEMBL436361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432447 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL117961 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL115850 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL333241 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL117030 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL325856 | — | IC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL118521 | — | IC50 | = | 12170.0 | nM | 4.92 |
| CHEMBL118520 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL117622 | — | IC50 | = | 20560.0 | nM | 4.69 |
| CHEMBL117808 | — | IC50 | = | 29810.0 | nM | 4.53 |
| CHEMBL117463 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL116027 | — | IC50 | = | 55260.0 | nM | 4.26 |
| CHEMBL115747 | — | IC50 | = | 75800.0 | nM | 4.12 |
| CHEMBL102740 | ARCAINE | IC50 | = | 79980.0 | nM | 4.10 |
| CHEMBL116333 | — | IC50 | = | 95210.0 | nM | 4.02 |
| CHEMBL117468 | — | IC50 | = | 112030.0 | nM | - |
| CHEMBL436361 | — | IC50 | = | 110500.0 | nM | - |