Assay Detail
Functional
CHEMBL747000
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Inhibitory activity against NMDA open channel block
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel benzo[b]quinolizinium cations as uncompetitive N-methyl-D-aspartic acid (NMDA) antagonists: the relationship between log D and agonist independent (closed) NMDA channel block.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.39 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202358 | — | — | 1 | 8.14 |
| CHEMBL1202359 | — | — | 1 | 8.04 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 7.64 |
| CHEMBL419052 | — | — | 1 | 7.57 |
| CHEMBL329612 | — | — | 1 | 7.50 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.57 |
| CHEMBL1202354 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202358 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1202359 | — | IC50 | = | 9.13 | nM | 8.04 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL419052 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL329612 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1202354 | — | IC50 | = | 557.0 | nM | 6.25 |