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Assay Detail

CHEMBL747048

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Functional
Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 1 (CHEMBL2587)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Discovery of potent and selective small molecule NPY Y5 receptor antagonists.
Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C.
Bioorg Med Chem Lett (2002) 12 : 1767 -1769
PubMed 12067557 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.66 4.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299879 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299879 Ki = 22000.0 nM 4.66