Assay Detail
Binding
CHEMBL747054
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Binding affinity against SMS-KAN cell membranes endogenously expressing Neuropeptide Y receptor type 2 using [125I]PYY as radioligand
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SMS-KAN |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Differentially functionalized diamines as novel ligands for the NPY2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.78 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95501 | — | — | 3 | 6.35 |
| CHEMBL328861 | — | — | 1 | 6.00 |
| CHEMBL98875 | — | — | 1 | 5.66 |
| CHEMBL95660 | — | — | 1 | 5.43 |
| CHEMBL328860 | — | — | 1 | 5.00 |
| CHEMBL97046 | — | — | 1 | - |
| CHEMBL420630 | — | — | 1 | - |
| CHEMBL99586 | — | — | 1 | - |
| CHEMBL319562 | — | — | 1 | - |
| CHEMBL317554 | — | — | 1 | - |
| CHEMBL95327 | — | — | 1 | - |
| CHEMBL100162 | — | — | 1 | - |
| CHEMBL95963 | — | — | 1 | - |
| CHEMBL317075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95501 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL95501 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL95501 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL328861 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98875 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL95660 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL328860 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL97046 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL420630 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99586 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL319562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL317554 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL95327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL100162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL95963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL317075 | — | IC50 | > | 10000.0 | nM | - |