Assay Detail
Binding
CHEMBL747056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 2 in SMS-KAN cell membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SMS-KAN |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.12 | 4.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41686 | — | — | 1 | 4.23 |
| CHEMBL290175 | — | — | 1 | 4.11 |
| CHEMBL41457 | — | — | 1 | 4.01 |
| CHEMBL41673 | — | — | 1 | - |
| CHEMBL41981 | — | — | 1 | - |
| CHEMBL42747 | — | — | 1 | - |
| CHEMBL44246 | — | — | 1 | - |
| CHEMBL42686 | — | — | 1 | - |
| CHEMBL288355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41686 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL290175 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL41457 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL41673 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL41981 | — | IC50 | = | 540000.0 | nM | - |
| CHEMBL42747 | — | IC50 | = | 247000.0 | nM | - |
| CHEMBL44246 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42686 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL288355 | — | IC50 | = | 575000.0 | nM | - |