Assay Detail
Binding
CHEMBL747111
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In vitro binding affinity towards N-methyl-D-aspartate glutamate receptor of the glutamate receptor using [3H]CPP as radioligand in rat cerebral cortical membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.75 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.00 |
| CHEMBL431029 | — | — | 1 | 6.96 |
| CHEMBL22304 | — | — | 1 | 6.88 |
| CHEMBL28862 | — | — | 1 | 6.75 |
| CHEMBL274440 | AP-7 | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL431029 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL22304 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL28862 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL274440 | AP-7 | Ki | = | 730.0 | nM | 6.14 |