Assay Detail
Binding
CHEMBL747201
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Inhibition of [3H]glycine binding to rat cortical membranes
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.96 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131567 | — | — | 1 | 5.89 |
| CHEMBL283819 | — | — | 2 | 5.85 |
| CHEMBL335231 | — | — | 2 | 4.90 |
| CHEMBL162442 | — | — | 1 | 4.82 |
| CHEMBL337030 | — | — | 1 | 4.72 |
| CHEMBL2115569 | — | — | 1 | 4.32 |
| CHEMBL165945 | — | — | 1 | 4.07 |
| CHEMBL350810 | — | — | 1 | - |
| CHEMBL165719 | — | — | 1 | - |
| CHEMBL351085 | — | — | 1 | - |
| CHEMBL433711 | — | — | 1 | - |
| CHEMBL350522 | — | — | 1 | - |
| CHEMBL162177 | — | — | 1 | - |
| CHEMBL350158 | — | — | 1 | - |
| CHEMBL351464 | — | — | 1 | - |
| CHEMBL353569 | — | — | 1 | - |
| CHEMBL2115541 | — | — | 1 | - |
| CHEMBL164785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131567 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL283819 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL283819 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL335231 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL162442 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL337030 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL335231 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL2115569 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL165945 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL350810 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165719 | — | IC50 | = | 313000.0 | nM | - |
| CHEMBL351085 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL350522 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL162177 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL350158 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL351464 | — | IC50 | = | 339000.0 | nM | - |
| CHEMBL353569 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2115541 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL164785 | — | IC50 | > | 100000.0 | nM | - |