Assay Detail
Binding
CHEMBL747228
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Binding constant towards human Opioid receptor kappa 1 was reported
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 9.12 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111838 | — | — | 1 | 9.77 |
| CHEMBL123898 | — | — | 1 | 9.60 |
| CHEMBL341056 | — | — | 1 | 9.55 |
| CHEMBL127463 | — | — | 1 | 9.52 |
| CHEMBL341529 | — | — | 1 | 9.44 |
| CHEMBL2111836 | — | — | 1 | 9.37 |
| CHEMBL126688 | — | — | 1 | 9.35 |
| CHEMBL338391 | — | — | 1 | 9.32 |
| CHEMBL334156 | — | — | 1 | 9.27 |
| CHEMBL127968 | — | — | 1 | 9.26 |
| CHEMBL2111837 | — | — | 1 | 9.16 |
| CHEMBL340001 | — | — | 1 | 8.88 |
| CHEMBL126282 | — | — | 1 | 8.81 |
| CHEMBL126596 | — | — | 1 | 8.42 |
| CHEMBL338393 | — | — | 1 | 8.36 |
| CHEMBL127619 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111838 | — | Ki | = | 0.1698 | nM | 9.77 |
| CHEMBL123898 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL341056 | — | Ki | = | 0.2818 | nM | 9.55 |
| CHEMBL127463 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL341529 | — | Ki | = | 0.3631 | nM | 9.44 |
| CHEMBL2111836 | — | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL126688 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL338391 | — | Ki | = | 0.4786 | nM | 9.32 |
| CHEMBL334156 | — | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL127968 | — | Ki | = | 0.5495 | nM | 9.26 |
| CHEMBL2111837 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL340001 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL126282 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL126596 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL338393 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL127619 | — | Ki | = | 13.49 | nM | 7.87 |