Assay Detail
Binding
CHEMBL747297
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Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Acyclic NK1 antagonists: Replacements for the benzhydryl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.50 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417784 | — | — | 1 | 8.03 |
| CHEMBL71498 | — | — | 1 | 7.26 |
| CHEMBL433107 | — | — | 1 | 7.10 |
| CHEMBL69051 | — | — | 1 | 7.03 |
| CHEMBL305274 | — | — | 1 | 6.32 |
| CHEMBL302719 | — | — | 1 | 5.94 |
| CHEMBL68670 | — | — | 1 | 5.63 |
| CHEMBL68934 | — | — | 1 | 5.63 |
| CHEMBL71553 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417784 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL71498 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL433107 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL69051 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL305274 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL302719 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL68670 | — | IC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL68934 | — | IC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL71553 | — | IC50 | = | 2500.0 | nM | 5.60 |