Assay Detail
Binding
CHEMBL747299
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Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Piperidine-ether based hNK1 antagonists 2: Investigation of the effect of N-substitution
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.17 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63793 | — | — | 1 | 9.52 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.22 |
| CHEMBL63240 | — | — | 1 | 9.20 |
| CHEMBL27006 | — | — | 1 | 9.06 |
| CHEMBL27003 | — | — | 1 | 8.89 |
| CHEMBL67667 | — | — | 1 | 8.74 |
| CHEMBL63762 | — | — | 1 | 8.57 |
| CHEMBL67612 | — | — | 1 | 8.55 |
| CHEMBL432279 | — | — | 1 | 7.85 |
| CHEMBL63257 | — | — | 1 | 7.60 |
| CHEMBL63278 | — | — | 1 | 7.46 |
| CHEMBL302315 | — | — | 1 | 7.17 |
| CHEMBL292496 | — | — | 1 | 7.07 |
| CHEMBL65153 | — | — | 1 | 6.96 |
| CHEMBL303181 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63793 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL63240 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL27006 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL27003 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL67667 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL63762 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL67612 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL432279 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL63257 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL63278 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL302315 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL292496 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL65153 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL303181 | — | IC50 | = | 227.0 | nM | 6.64 |