Assay Detail
Functional
CHEMBL747321
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In Vitro 5-HT3 agonist activity on the [14C]guanidinium accumulation in NG 108-15 cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NG108-15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.33 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54720 | — | — | 1 | 7.96 |
| CHEMBL53416 | — | — | 1 | 7.75 |
| CHEMBL53573 | — | — | 1 | 7.50 |
| CHEMBL299634 | — | — | 1 | 7.28 |
| CHEMBL53662 | — | — | 1 | 6.98 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54720 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL53416 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL53573 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL299634 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL53662 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL39 | SEROTONIN | EC50 | = | 293.0 | nM | 6.53 |