Assay Detail
Functional
CHEMBL747322
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In vitro effective concentration against [14C]guanidinium uptake into NG 108-15 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NG108-15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.73 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52772 | — | — | 1 | 8.30 |
| CHEMBL54720 | — | — | 1 | 8.00 |
| CHEMBL65710 | — | — | 1 | 7.52 |
| CHEMBL301765 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52772 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL54720 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL65710 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL301765 | — | EC50 | = | 80.0 | nM | 7.10 |