Assay Detail
Functional
CHEMBL747324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Quantitative effect on the [14C]guanidinium accumulation in NG 108-15 cells (mouse neuroblastoma and rat glioma hybrid cells)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NG108-15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.24 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43355 | — | — | 1 | 9.60 |
| CHEMBL288497 | — | — | 1 | 8.15 |
| CHEMBL43193 | — | — | 1 | 8.00 |
| CHEMBL43512 | — | — | 1 | 7.92 |
| CHEMBL38843 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43355 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL288497 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL43193 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43512 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL38843 | — | EC50 | = | 30.0 | nM | 7.52 |