Assay Detail
Functional
CHEMBL747328
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Effective concentration for uptake of [14C]guanidinium on NG108-15 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NG108-15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.65 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341474 | — | — | 1 | 8.52 |
| CHEMBL120216 | — | — | 1 | 8.46 |
| CHEMBL120215 | — | — | 1 | 8.33 |
| CHEMBL124886 | — | — | 1 | 8.19 |
| CHEMBL122835 | — | — | 1 | 8.10 |
| CHEMBL121076 | — | — | 1 | 8.09 |
| CHEMBL421059 | — | — | 1 | 8.07 |
| CHEMBL327197 | — | — | 1 | 8.00 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.60 |
| CHEMBL121687 | — | — | 1 | 7.52 |
| CHEMBL332328 | — | — | 1 | 7.14 |
| CHEMBL121155 | — | — | 1 | 7.12 |
| CHEMBL331304 | — | — | 1 | 7.01 |
| CHEMBL123137 | — | — | 1 | 6.29 |
| CHEMBL126041 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341474 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL120216 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL120215 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL124886 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL122835 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL121076 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL421059 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL327197 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL18772 | QUIPAZINE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL121687 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL332328 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL121155 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL331304 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL123137 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL126041 | — | EC50 | = | 580.0 | nM | 6.24 |