Assay Detail
Binding
CHEMBL747363
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Compound was evaluated for the inhibition of the binding of [3H]CPP against N-methyl-D-aspartate glutamate receptor in mice
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.18 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22304 | — | — | 1 | 7.14 |
| CHEMBL40024 | — | — | 1 | 6.92 |
| CHEMBL165642 | — | — | 1 | 5.46 |
| CHEMBL355615 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22304 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL40024 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL165642 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL355615 | — | IC50 | = | 6600.0 | nM | 5.18 |