Assay Detail
Binding
CHEMBL747420
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Tested for inhibition of Myosin light chain kinase from chicken gizzard
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Meleagris gallopavo |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Myosin light chain kinase, smooth muscle (CHEMBL2428) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.00 |
| CHEMBL155929 | — | — | 1 | 7.75 |
| CHEMBL348563 | — | — | 1 | 7.52 |
| CHEMBL156433 | — | — | 1 | 7.50 |
| CHEMBL347154 | — | — | 1 | 7.31 |
| CHEMBL348177 | — | — | 1 | 7.26 |
| CHEMBL156172 | — | — | 1 | 6.92 |
| CHEMBL157822 | — | — | 1 | 6.92 |
| CHEMBL348902 | — | — | 1 | 6.75 |
| CHEMBL345593 | — | — | 1 | 6.70 |
| CHEMBL157967 | — | — | 1 | 6.66 |
| CHEMBL157892 | — | — | 1 | 6.60 |
| CHEMBL157528 | — | — | 1 | 6.51 |
| CHEMBL154245 | — | — | 1 | 6.41 |
| CHEMBL346467 | — | — | 1 | 5.80 |
| CHEMBL346038 | — | — | 1 | 5.26 |
| CHEMBL302449 | GO-6976 | — | 1 | 5.24 |
| CHEMBL345639 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL155929 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL348563 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL156433 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL347154 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL348177 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL156172 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL157822 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL348902 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL345593 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL157967 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL157892 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL157528 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL154245 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL346467 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL346038 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL302449 | GO-6976 | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL345639 | — | IC50 | = | 9200.0 | nM | 5.04 |