Assay Detail
Functional
CHEMBL747899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]guanidinium uptake on NG108-15 cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Cell Type | NG108-15 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 8.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 9.00 |
| CHEMBL139327 | — | — | 1 | 8.80 |
| CHEMBL423899 | — | — | 1 | 8.77 |
| CHEMBL136449 | — | — | 1 | 8.62 |
| CHEMBL136090 | — | — | 1 | 8.57 |
| CHEMBL341474 | — | — | 1 | 8.52 |
| CHEMBL136978 | — | — | 1 | 8.42 |
| CHEMBL137621 | — | — | 1 | 8.38 |
| CHEMBL342447 | — | — | 1 | 8.38 |
| CHEMBL337324 | — | — | 1 | 8.18 |
| CHEMBL136524 | — | — | 1 | 8.14 |
| CHEMBL342690 | — | — | 1 | 8.02 |
| CHEMBL136536 | — | — | 1 | 7.92 |
| CHEMBL422279 | — | — | 1 | 7.85 |
| CHEMBL136525 | — | — | 1 | 7.82 |
| CHEMBL53573 | — | — | 1 | 7.50 |
| CHEMBL136108 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL139327 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL423899 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL136449 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL136090 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL341474 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL136978 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL137621 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL342447 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL337324 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL136524 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL342690 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL136536 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL422279 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL136525 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL53573 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL136108 | — | EC50 | = | 54.0 | nM | 7.27 |