Assay Detail
Functional
CHEMBL747940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antitumor activity against NSCL NCI-H226 tumor cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.88 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334648 | RORIDIN A | — | 1 | 8.52 |
| CHEMBL136985 | VERRUCARIN A | — | 1 | 8.40 |
| CHEMBL335838 | — | — | 1 | 8.15 |
| CHEMBL136396 | VERRUCARRIN M | — | 1 | 7.48 |
| CHEMBL136268 | RORIDIN L | — | 1 | 7.04 |
| CHEMBL435984 | RORIDIN M | — | 1 | 6.80 |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | — | 1 | 5.31 |
| CHEMBL136186 | TRICHOVERRIN B | — | 1 | 5.16 |
| CHEMBL136053 | TRICHOVERRIN A | — | 1 | 5.08 |
| CHEMBL433680 | ANGUIDIN | — | 1 | - |
| CHEMBL2368056 | Miophytocen C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334648 | RORIDIN A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL136985 | VERRUCARIN A | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL335838 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL136396 | VERRUCARRIN M | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL136268 | RORIDIN L | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL435984 | RORIDIN M | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL136186 | TRICHOVERRIN B | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL136053 | TRICHOVERRIN A | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL433680 | ANGUIDIN | IC50 | < | 1.0 | nM | - |
| CHEMBL2368056 | Miophytocen C | IC50 | > | 10000.0 | nM | - |