Assay Detail
Binding
CHEMBL747966
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Inhibition of NADH decylubiquinone (DB) oxidoreductase activity.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.23 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145554 | — | — | 1 | 9.54 |
| CHEMBL358586 | — | — | 1 | 9.41 |
| CHEMBL145449 | BULLANIN | — | 1 | 9.36 |
| CHEMBL144981 | — | — | 1 | 9.35 |
| CHEMBL142276 | — | — | 1 | 9.22 |
| CHEMBL1159657 | BULLATACIN | — | 1 | 9.21 |
| CHEMBL141607 | — | — | 1 | 9.17 |
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 9.13 |
| CHEMBL41177 | SQUAMOCIN | — | 1 | 9.11 |
| CHEMBL66691 | MOTRILIN | — | 1 | 9.09 |
| CHEMBL145222 | — | — | 1 | 9.08 |
| CHEMBL359434 | — | — | 1 | 9.05 |
| CHEMBL357666 | — | — | 1 | 8.89 |
| CHEMBL145455 | — | — | 1 | 8.72 |
| CHEMBL145624 | GUANACONE | — | 1 | 8.68 |
| CHEMBL145484 | — | — | 1 | 8.60 |
| CHEMBL145064 | — | — | 1 | 7.19 |
| CHEMBL357600 | — | — | 1 | 6.61 |
| CHEMBL344296 | — | — | 1 | 6.50 |
| CHEMBL145555 | — | — | 1 | 6.36 |
| CHEMBL145485 | — | — | 1 | 5.72 |
| CHEMBL145073 | — | — | 1 | 5.69 |
| CHEMBL145563 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145554 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL358586 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL145449 | BULLANIN | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL144981 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL142276 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1159657 | BULLATACIN | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL141607 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL66691 | MOTRILIN | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL145222 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL359434 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL357666 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL145455 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL145624 | GUANACONE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL145484 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL145064 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL357600 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL344296 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL145555 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL145485 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL145073 | — | IC50 | = | 2037.0 | nM | 5.69 |
| CHEMBL145563 | — | IC50 | = | 2936.0 | nM | 5.53 |