Assay Detail
Binding
CHEMBL747968
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Tested for the ability to block NADH dehydrogenase in a preparation of submitochondrial particles obtained from blow fly flight muscle
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Calliphoridae |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural requirements for respiratory inhibition by rotenoids; is an intact B/C ring system essential?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429023 | ROTENONE | — | 1 | 8.70 |
| CHEMBL342274 | — | — | 1 | 7.90 |
| CHEMBL148538 | — | — | 1 | 7.82 |
| CHEMBL357845 | — | — | 1 | 7.30 |
| CHEMBL148863 | — | — | 1 | 6.82 |
| CHEMBL356701 | — | — | 1 | 6.76 |
| CHEMBL149428 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429023 | ROTENONE | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL342274 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL148538 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL357845 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL148863 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL356701 | — | IC50 | = | 173.78 | nM | 6.76 |
| CHEMBL149428 | — | IC50 | = | 251.19 | nM | 6.60 |