Assay Detail
Binding
CHEMBL748017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](-)-cytisine from rat brain nicotinic acetylcholine receptors (nAChR)
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-(R) and (S) pyrrolidine-modified analogs of the cholinergic channel activator, ABT-418
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.32 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274525 | ABT-418 | — | 1 | 8.52 |
| CHEMBL268750 | — | — | 1 | 8.13 |
| CHEMBL14743 | — | — | 1 | 7.72 |
| CHEMBL274979 | — | — | 2 | 7.15 |
| CHEMBL275173 | — | — | 1 | 6.81 |
| CHEMBL14839 | — | — | 1 | 6.02 |
| CHEMBL14554 | — | — | 1 | 5.77 |
| CHEMBL15244 | — | — | 1 | 5.22 |
| CHEMBL14537 | — | — | 1 | 5.18 |
| CHEMBL2079554 | — | — | 1 | 5.09 |
| CHEMBL15212 | — | — | 1 | 4.96 |
| CHEMBL277559 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274525 | ABT-418 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL268750 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL14743 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL274979 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL275173 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL274979 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL14839 | — | Ki | = | 946.0 | nM | 6.02 |
| CHEMBL14554 | — | Ki | = | 1683.0 | nM | 5.77 |
| CHEMBL15244 | — | Ki | = | 6036.0 | nM | 5.22 |
| CHEMBL14537 | — | Ki | = | 6646.0 | nM | 5.18 |
| CHEMBL2079554 | — | Ki | = | 8136.0 | nM | 5.09 |
| CHEMBL15212 | — | Ki | = | 10883.0 | nM | 4.96 |
| CHEMBL277559 | — | Ki | = | 16946.0 | nM | 4.77 |