Assay Detail
Functional
CHEMBL748030
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The IC50 value was measured on NCl-H460 cell line in NSCL tumor type
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.27 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.30 |
| CHEMBL44919 | — | — | 1 | 8.38 |
| CHEMBL42819 | — | — | 1 | 7.85 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL44919 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL42819 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 28.0 | nM | 7.55 |