Assay Detail
Functional
CHEMBL748094
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Inhibitory activity of compound against NL4-3 (T) tropic virus that utilizes the CXCR-4 co-receptor was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | nl4-3 tropic virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.11 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337301 | — | — | 1 | 8.53 |
| CHEMBL135339 | — | — | 1 | 7.51 |
| CHEMBL336293 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337301 | — | EC50 | = | 2.94 | nM | 8.53 |
| CHEMBL135339 | — | EC50 | = | 30.8 | nM | 7.51 |
| CHEMBL336293 | — | EC50 | = | 5130.0 | nM | 5.29 |