Assay Detail
Binding
CHEMBL748118
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Concentration producing half maximal displacement of [3H]NPY specific binding from benextramine sensitive NPY binding sites in rat brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nonpeptide peptidomimetic antagonists of the neuropeptide Y receptor: benextramine analogs with selectivity for the peripheral Y2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.58 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160389 | — | — | 1 | 4.83 |
| CHEMBL1160387 | — | — | 1 | 4.82 |
| CHEMBL1160388 | — | — | 1 | 4.74 |
| CHEMBL42671 | — | — | 1 | 4.50 |
| CHEMBL72075 | — | — | 1 | 4.32 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160389 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1160387 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1160388 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL42671 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL72075 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 57600.0 | nM | 4.24 |