Assay Detail
Functional
CHEMBL748128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human ovarian OVCAR-3 cell lines.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.86 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.24 |
| CHEMBL146785 | — | — | 1 | 8.17 |
| CHEMBL147372 | — | — | 1 | 7.92 |
| CHEMBL144014 | — | — | 1 | 7.66 |
| CHEMBL343913 | — | — | 1 | 7.64 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL344310 | — | — | 1 | 7.41 |
| CHEMBL149293 | — | — | 1 | 7.28 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.24 |
| CHEMBL148281 | — | — | 1 | 7.19 |
| CHEMBL356785 | — | — | 1 | 7.17 |
| CHEMBL147576 | — | — | 1 | 7.11 |
| CHEMBL422137 | — | — | 1 | 7.11 |
| CHEMBL356797 | — | — | 1 | 6.99 |
| CHEMBL345020 | — | — | 1 | 6.91 |
| CHEMBL149184 | — | — | 1 | 6.75 |
| CHEMBL146559 | — | — | 1 | 6.67 |
| CHEMBL148344 | — | — | 1 | 6.64 |
| CHEMBL147428 | — | — | 1 | 6.46 |
| CHEMBL358993 | — | — | 1 | 6.29 |
| CHEMBL439812 | — | — | 1 | 6.26 |
| CHEMBL343852 | — | — | 1 | 6.15 |
| CHEMBL439632 | — | — | 1 | 5.72 |
| CHEMBL146516 | — | — | 1 | 5.67 |
| CHEMBL422843 | — | — | 1 | 5.26 |
| CHEMBL148229 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL146785 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL147372 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144014 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL343913 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL344310 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL149293 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL148281 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL356785 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL147576 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL422137 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL356797 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL345020 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL149184 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL146559 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL148344 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL147428 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL358993 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL439812 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL343852 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL439632 | — | IC50 | = | 1887.0 | nM | 5.72 |
| CHEMBL146516 | — | IC50 | = | 2126.0 | nM | 5.67 |
| CHEMBL422843 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL148229 | — | IC50 | = | 8997.0 | nM | 5.05 |