Assay Detail
Functional
CHEMBL748137
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Inhibitory activity against OVCAR-3 cell line
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.89 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40865 | — | — | 1 | 9.10 |
| CHEMBL42100 | — | — | 1 | 8.89 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.24 |
| CHEMBL43809 | — | — | 1 | 8.06 |
| CHEMBL40716 | — | — | 1 | 7.92 |
| CHEMBL42201 | — | — | 1 | 7.72 |
| CHEMBL42571 | — | — | 1 | 7.72 |
| CHEMBL40776 | — | — | 1 | 7.55 |
| CHEMBL40515 | — | — | 1 | 7.51 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.24 |
| CHEMBL44207 | — | — | 1 | 7.20 |
| CHEMBL41290 | — | — | 1 | 7.17 |
| CHEMBL41450 | — | — | 1 | 7.03 |
| CHEMBL42490 | — | — | 1 | 6.94 |
| CHEMBL288217 | — | — | 1 | 6.89 |
| CHEMBL40924 | — | — | 1 | 6.76 |
| CHEMBL40586 | — | — | 1 | 6.75 |
| CHEMBL40359 | — | — | 1 | 6.66 |
| CHEMBL40568 | — | — | 1 | 6.57 |
| CHEMBL289120 | — | — | 1 | 6.44 |
| CHEMBL416242 | — | — | 1 | 6.41 |
| CHEMBL43931 | — | — | 1 | 6.38 |
| CHEMBL288699 | — | — | 1 | 6.30 |
| CHEMBL43763 | — | — | 1 | 6.28 |
| CHEMBL40314 | — | — | 1 | 6.27 |
| CHEMBL290060 | — | — | 1 | 6.14 |
| CHEMBL40313 | — | — | 1 | 6.14 |
| CHEMBL296224 | — | — | 1 | 6.12 |
| CHEMBL287719 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40865 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL42100 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL43809 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL40716 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL42201 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL42571 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL40776 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL40515 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL44207 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL41290 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL41450 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL42490 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL288217 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL40924 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL40586 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL40359 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL40568 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL289120 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL416242 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL43931 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL288699 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL43763 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL40314 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL290060 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL40313 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL296224 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL287719 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL41561 | — | IC50 | = | 1179.0 | nM | 5.93 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL43920 | — | IC50 | = | 2883.0 | nM | 5.54 |
| CHEMBL289729 | — | IC50 | = | 6075.0 | nM | 5.22 |