Assay Detail
Functional
CHEMBL748189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth of NCI-H460 tumor cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.86 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62253 | — | — | 1 | 6.28 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.23 |
| CHEMBL59785 | — | — | 1 | 6.15 |
| CHEMBL64742 | — | — | 1 | 5.93 |
| CHEMBL293898 | — | — | 1 | 5.91 |
| CHEMBL61790 | — | — | 1 | 5.87 |
| CHEMBL291402 | — | — | 1 | 5.79 |
| CHEMBL302854 | — | — | 1 | 5.75 |
| CHEMBL293157 | — | — | 1 | 5.58 |
| CHEMBL64758 | — | — | 1 | 5.56 |
| CHEMBL292021 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62253 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL59785 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL64742 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL293898 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL61790 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL291402 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL302854 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL293157 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL64758 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL292021 | — | IC50 | = | 4220.0 | nM | 5.38 |