Assay Detail
Functional
CHEMBL748475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against acetylated LDL-induced accumulation of cholesteryl esters in mouse peritoneal macrophages
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.15 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136230 | — | — | 1 | 8.54 |
| CHEMBL138692 | — | — | 1 | 8.21 |
| CHEMBL139172 | — | — | 1 | 7.89 |
| CHEMBL336263 | — | — | 1 | 7.85 |
| CHEMBL136428 | — | — | 1 | 7.82 |
| CHEMBL134975 | — | — | 1 | 7.70 |
| CHEMBL139798 | — | — | 1 | 7.68 |
| CHEMBL139211 | — | — | 1 | 7.46 |
| CHEMBL343726 | — | — | 1 | 7.40 |
| CHEMBL342476 | — | — | 1 | 7.33 |
| CHEMBL77842 | — | — | 1 | 7.32 |
| CHEMBL436603 | — | — | 1 | 7.28 |
| CHEMBL139220 | — | — | 1 | 7.10 |
| CHEMBL440722 | — | — | 1 | 6.96 |
| CHEMBL138323 | — | — | 1 | 6.67 |
| CHEMBL344456 | — | — | 1 | 6.62 |
| CHEMBL139273 | — | — | 1 | 6.58 |
| CHEMBL138214 | — | — | 1 | 6.46 |
| CHEMBL311725 | — | — | 1 | 6.46 |
| CHEMBL136438 | — | — | 1 | 6.46 |
| CHEMBL344868 | — | — | 1 | 6.46 |
| CHEMBL78870 | — | — | 1 | 5.13 |
| CHEMBL140181 | — | — | 1 | - |
| CHEMBL136368 | — | — | 1 | - |
| CHEMBL342491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136230 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL138692 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL139172 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL336263 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL136428 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL134975 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL139798 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL139211 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL343726 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL342476 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL77842 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL436603 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL139220 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL440722 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL138323 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL344456 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL139273 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL138214 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL311725 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL136438 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL344868 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL78870 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL140181 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL136368 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL342491 | — | IC50 | < | 10.0 | nM | - |