Assay Detail
Binding
CHEMBL748487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.31 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53312 | — | — | 1 | 9.00 |
| CHEMBL27006 | — | — | 1 | 9.00 |
| CHEMBL54540 | — | — | 1 | 8.77 |
| CHEMBL54602 | — | — | 1 | 8.48 |
| CHEMBL55240 | — | — | 1 | 8.18 |
| CHEMBL51794 | — | — | 1 | 8.11 |
| CHEMBL417760 | — | — | 1 | 7.96 |
| CHEMBL433285 | — | — | 1 | 7.92 |
| CHEMBL445357 | — | — | 1 | 7.89 |
| CHEMBL292156 | — | — | 1 | 7.75 |
| CHEMBL55229 | — | — | 1 | 7.64 |
| CHEMBL52139 | — | — | 1 | 7.62 |
| CHEMBL300896 | — | — | 1 | 7.57 |
| CHEMBL52717 | — | — | 1 | 7.48 |
| CHEMBL299016 | — | — | 1 | 7.47 |
| CHEMBL301630 | — | — | 1 | 7.44 |
| CHEMBL299388 | — | — | 1 | 7.38 |
| CHEMBL54940 | — | — | 1 | 7.37 |
| CHEMBL55098 | — | — | 1 | 7.27 |
| CHEMBL298772 | — | — | 1 | 7.26 |
| CHEMBL417914 | — | — | 1 | 7.24 |
| CHEMBL300005 | — | — | 1 | 7.24 |
| CHEMBL417731 | — | — | 1 | 7.22 |
| CHEMBL50455 | — | — | 1 | 7.20 |
| CHEMBL52070 | — | — | 1 | 7.15 |
| CHEMBL56003 | — | — | 1 | 7.10 |
| CHEMBL54717 | — | — | 1 | 7.10 |
| CHEMBL292404 | — | — | 1 | 7.06 |
| CHEMBL52892 | — | — | 1 | 7.00 |
| CHEMBL55180 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53312 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL27006 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL54540 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL54602 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL55240 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL51794 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL417760 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL433285 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL445357 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL292156 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL55229 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL52139 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL300896 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL52717 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL299016 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL301630 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL299388 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL54940 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL55098 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL298772 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL417914 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL300005 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL417731 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL50455 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL52070 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL56003 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL54717 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL292404 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL52892 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55180 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL55129 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL54996 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL51863 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL51849 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL54578 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL54435 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL301008 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL292211 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL294843 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL292874 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL56069 | — | IC50 | = | 2000.0 | nM | 5.70 |