Assay Detail
Binding
CHEMBL748488
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Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53312 | — | — | 1 | 9.00 |
| CHEMBL292190 | — | — | 1 | 8.32 |
| CHEMBL53314 | — | — | 1 | 7.89 |
| CHEMBL405820 | — | — | 1 | 7.77 |
| CHEMBL299528 | — | — | 1 | 7.21 |
| CHEMBL417026 | — | — | 1 | 6.58 |
| CHEMBL299312 | — | — | 1 | 6.48 |
| CHEMBL54931 | — | — | 1 | 6.42 |
| CHEMBL297957 | — | — | 1 | 6.26 |
| CHEMBL52198 | — | — | 1 | 6.25 |
| CHEMBL299089 | — | — | 1 | 6.22 |
| CHEMBL55691 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53312 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL292190 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL53314 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL405820 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL299528 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL417026 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL299312 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL54931 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL297957 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL52198 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL299089 | — | IC50 | = | 602.0 | nM | 6.22 |
| CHEMBL55691 | — | IC50 | = | 2500.0 | nM | 5.60 |