Assay Detail
Binding
CHEMBL748489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.34 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288371 | — | — | 1 | 8.05 |
| CHEMBL289666 | — | — | 1 | 7.82 |
| CHEMBL295845 | — | — | 1 | 7.42 |
| CHEMBL131171 | — | — | 1 | 7.31 |
| CHEMBL288942 | — | — | 1 | 7.29 |
| CHEMBL291146 | — | — | 1 | 7.08 |
| CHEMBL41375 | — | — | 1 | 6.43 |
| CHEMBL38824 | DAPITANT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288371 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL289666 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL295845 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL131171 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL288942 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL291146 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL41375 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL38824 | DAPITANT | IC50 | = | 13.0 | nM | - |