Assay Detail

CHEMBL748559

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Binding

Compound was tested for binding activity against N-methyl-D-aspartic acid(NMDA) receptor in rat brain crude synaptic membranes

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Tissue	Brain
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Asymmetric synthesis of cis-()-(2R4S)-4-(phosphonomethyl)-2-piperidinecarboxylic acid, a potent NMDA receptor antagonist

Skiles JW, Giannousis PP, Fales KR
Bioorg Med Chem Lett (1996) 6 : 963 -966
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.57	7.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39664	SELFOTEL	2.0	3	7.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39664	SELFOTEL	IC50	=	29.0	nM	7.54
CHEMBL39664	SELFOTEL	IC50	=	69.0	nM	7.16
CHEMBL39664	SELFOTEL	IC50	=	10000.0	nM	5.00