Assay Detail
Binding
CHEMBL748572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2-carboxy indolines and indoles as potential glycine/NMDA antagonists: effect of five-membered ring conformation on affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.51 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42871 | — | — | 1 | 7.57 |
| CHEMBL43372 | — | — | 1 | 7.44 |
| CHEMBL31344 | — | — | 1 | 7.16 |
| CHEMBL42415 | — | — | 1 | 6.09 |
| CHEMBL415462 | — | — | 1 | 5.75 |
| CHEMBL43307 | — | — | 1 | 5.05 |
| CHEMBL42416 | — | — | 1 | - |
| CHEMBL42323 | — | — | 1 | - |
| CHEMBL42499 | — | — | 1 | - |
| CHEMBL298435 | — | — | 1 | - |
| CHEMBL46910 | — | — | 1 | - |
| CHEMBL42380 | — | — | 1 | - |
| CHEMBL295647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42871 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL43372 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL31344 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL42415 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL415462 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL43307 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL42416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42323 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL42499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298435 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL46910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42380 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295647 | — | IC50 | > | 100000.0 | nM | - |