Assay Detail
Functional
CHEMBL748619
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Compound is screened in AP1 cells expressing human NHE-5 for sodium hydrogen exchange activity
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | AP1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.47 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51879 | — | — | 1 | 5.47 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | - |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51879 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL64360 | ENIPORIDE | IC50 | > | 30000.0 | nM | - |
| CHEMBL436559 | CARIPORIDE | IC50 | > | 30000.0 | nM | - |