Assay Detail
Binding
CHEMBL748706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.35 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.59 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 7.01 |
| CHEMBL295680 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 97.5 | nM | 7.01 |
| CHEMBL295680 | — | IC50 | = | 3500.0 | nM | 5.46 |