Assay Detail
Binding
CHEMBL748708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-9 (CHEMBL2585) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 9.89 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134341 | — | — | 1 | 10.57 |
| CHEMBL135897 | — | — | 1 | 10.57 |
| CHEMBL134418 | — | — | 1 | 10.55 |
| CHEMBL337276 | — | — | 1 | 10.44 |
| CHEMBL336118 | — | — | 1 | 10.43 |
| CHEMBL135684 | — | — | 1 | 10.35 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.30 |
| CHEMBL335204 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134341 | — | Kd | = | 0.027 | nM | 10.57 |
| CHEMBL135897 | — | Kd | = | 0.027 | nM | 10.57 |
| CHEMBL134418 | — | Kd | = | 0.028 | nM | 10.55 |
| CHEMBL337276 | — | Kd | = | 0.036 | nM | 10.44 |
| CHEMBL336118 | — | Kd | = | 0.037 | nM | 10.43 |
| CHEMBL135684 | — | Kd | = | 0.045 | nM | 10.35 |
| CHEMBL3 | NICOTINE | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL335204 | — | Kd | = | 13.6 | nM | 7.87 |